Autophagy & AO Scan = Longevity

autophagy

Exploring Autophagy: Potential to Increase Life Span

The body has a method of eliminating harmful organisms and toxins known as detoxification.

This allows the cells, organs, and immune system to work at their best.

That is not the only way the body heals itself.

It has been discovered that a process is essential for getting rid of damaged cells and repurposing their components into new ones to maintain equilibrium.

Detoxification and Autophagy Decrease with age and can be impacted by lifestyle choices. Nevertheless, they are still necessary processes.

Autophagy: What is it?

The Greek term “autophagy” can be translated to “self-eating,” meaning that the body carries out a self-degradative action that removes misfolded proteins, unhealthy cells, and disease-causing agents.

The cellular components are then reused to build new and healthy cells.

Moxley, an exercise physiologist and the director of applied sciences at Longevity Labs, explained to Healthnews that “a built-in cellular detoxification process is found in all creatures.

This is why much of the research used fruit flies and mice before the studies were done with humans.”

Christian de Duve, a scientist from Belgium, first used the term “lysosomes” in 1962 during his research on the digestive organelles of a cell.

Autophagy & The Nobel Prize

This research was acknowledged with a Nobel Prize shared with two other scientists in 1974.

It wasn’t until Yoshinori Ohsumi, a Japanese cell biologist, won the Nobel Prize in Physiology or Medicine in 2016 for discovering mechanisms for autopAutophagyt that autopAutophagyme became mainstream almost 40 years later.

Fasting, heat/sauna treatments, and various dietary supplements have been increasingly employed to increase Autophagy, promoting better health and a greater lifespan.

It has been demonstrated that Autophagy is beneficial for treating several illnesses, such as Alzheimer’s Disease, Type 2 Diabetes, and cardiovascular disease. However, much is still to be discovered regarding a complete comprehension of Autophagy. What is the Process of Autophagy?

Moxley pointed out that autopAutophagyn is an ongoing process within the cell, so it is not simply a matter of turning it “on and off.” Depending on the circumstances, it is possible to increase or decrease it, which we will look at in the subsequent section.

The body’s induction of autopAutophagyften is sparked by a lack of nutrients or oxygen that it usually uses to generate energy. In this situation, the organism will look inward and break down aged and dysfunctional cells into their components to build new cells.

Lifespan Expert Weighs In

In his book “Lifespan,” David Sinclair explains Autophagy, which is the process in which cells become more conservative, recycling older components to provide energy and lengthen their existence.

In the distant past, when food was scarce, Autophagy was an essential mechanism for our ancestors to survive. This process enabled them to maintain equilibrium in the body.

Research has revealed that Autophagy is the accumulation of decrepit and aged cells that induce inflammation and reduce cell functionality. Consequently, it can be a potential treatment for illnesses connected to inflammation.

How can autopAutophagyst with the prolonging of life and contribute to one’s overall health?

It is becoming widely accepted that health and healthy aging commence on a cellular level. If your cells and mitochondria perform optimally, your organs will work efficiently; thus, your entire body will be in optimal condition.

Your daily habits, such as eating, exercising, and sleeping, can either positively or negatively affect your cells and your body’s inflammation. Autophagy, which activates the body’s survival mechanism, can help to fix errors and potentially reduce the effects of aging.

More on Autophagy

Autophagy has been linked to anti-aging as it is known to activate the anti-aging gene (Sirtuin 1), reduce the production of reactive oxygen species and inflammation, aid in cell repair, and increase the output of brain-protective substances.

Moxley explained that Autophagy is beneficial for numerous ailments and that this is likely due to its ability to reduce inflammation.

According to research from Harvard Health, chronic inflammation is at the root of numerous preventable modern diseases.

Autophagy Decreases Inflammation

He noted that an increase in Autophagy is usually met with a decrease in inflammation and that 67 proteins related to Autophagy have been discovered.

He explained that the more Autophagy is increased, the more inflammation is suppressed. He furthermore pointed out that “inflammation” is a phenomenon in which inflammation accelerates the aging process.

A research paper published in Nature recently shed light on Autophagy’s cognitive advantages. The investigation concluded that autophagynstrumental raises BDNF signaling, which helps maintain cognitive efficiency and encourages neuroplasticity.

Specific elements can potentially hinder the process of autopautophagy, which can be listed as follows.

Overeating

Frequent snacking

Being inactive

Techniques for Boosting Autophagy

Caloric limitation and abstaining from food

Intermittent fasting and time-restricted eating have been found to induce Sirtuin 1 gene (Sirt1) activation, which encourages Autophagy. According to a research article published in the Journal of Biological Chemistry, depriving the body of protein and carbohydrates disrupts mTOR (mammalian target of rapamycin) signaling, a process linked to autophagy stimulation.

It’s critical to include cycling in your routine. To promote the body’s “housekeeping” system,

it’s essential to provide healthy fats, proteins, and fiber to reactivate the mTOR pathway and create new cells.

You can let your body cleanse during fasting and then rebuild when you eat. Moxley suggests beginning with a 6-hour feeding/18-hour fasting or an 8-hour feeding/16-hour fasting schedule.

Using Dietary Supplements

Dietary supplements are becoming increasingly popular as people seek to improve their health, wellness, and overall quality of life.

These products, including pills, capsules, and powders, are available in various forms and can provide multiple benefits.

Supplements can provide essential vitamins and minerals that may be lacking in a person’s diet and offer additional nutrients for improved health and immunity.

Furthermore, taking supplements can help to reduce the risk of certain diseases and provide overall support for healthy living.

Two medications, metformin, and rapamycin, are often prescribed to inhibit mTOR activity and thereby stimulate Autophagy. A polyamine, spermidine, has been identified as promoting Autophagy. A recent study showed that dietary supplementation of this molecule increased life expectancy and reversed the detrimental effects of aging on the heart in mice by stimulating Autophagy through  Exercise.

Physical activity is an essential part of living a healthy lifestyle.

Exercise is a great way to stay in shape, improve physical and mental health, and reduce stress. Regular exercise can also help prevent or reduce the severity of various health conditions and improve overall well-being.

Finding an activity that suits your needs and goals is essential.

Moxley encourages people to exercise for reasons other than weight loss.

He explains that this activity can help promote autophagy inflammation, generate healthier mitochondrial integrity, and increase AMPK.

As a bonus, weight loss and improved body composition will be side effects of these activities.

A diet high in fat and low in carbohydrates can result in ketosis

Investigations have revealed a favorable connection between ketogenic approaches, autophagy activation, and enhanced vascular health.

An individual can enter a state of ketosis through fasting or by consuming a diet of high fat, minimal carbohydrates, and moderate amounts of protein.

Utilizing Heat as Therapy

Heat therapy is helpful in many ways. It has been used to relieve pain, improve circulation, and reduce muscle tension, among other things.

Heat therapy, which uses hot packs, baths, or infrared light, can benefit those suffering from arthritis, sports injuries, or chronic pain.

Research detailed in the Journal of Applied Physiology concluded that the results from animal and cell culture experiments have demonstrated a potential benefit from heat therapy in terms of autopAutophagyever, further inquiry is required to ascertain if sauna use has the same effect on humans.

The CDC declared on January 18, 2023, that counties in states with an adult obesity prevalence of more than 40% are qualified to apply for a grant.

Furthermore, they have made new funding available.

Frequency Assessment Optimization & Autophagy

Frequency assessment and optimization can be done using the Premier Health Technology from Solex AO Scan.

The AO Scan helps move the body toward homeostasis, which moves the body in such a way to facilitate detoxification better, and ultimately autopAutophagy Scan Technology should serve as a foundational protocol when it comes to all things health & wellness.” says AO Scan Expert & Trainer,  Paige Maurer Wheeler, 

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